Where is the adrenal cortex located5/19/2023 In mammals, the circadian clock is a hierarchically organized multicomponent internal time-keeping system that synchronizes rhythms in physiology, metabolism and behavior to the 24 h solar day (Circa: about, dies: a day) ]. The circadian clock has developed very early during evolution to enable the organisms to anticipate daily rhythms in the environment such as the light/dark cycle. Better understanding of the role of the circadian system in modulation of adult neurogenesis can help develop new treatment strategies to improve the cognitive deterioration associated with chronodisruption due to detrimental light regimes or neurodegenerative diseases. In this review, we discuss the role of the circadian system for adult neurogenesis at both the systemic and the cellular levels. ![]() This modulatory effect may be exercised via rhythmic systemic factors including neurotransmitters, hormones and neurotrophic factors as well as rhythmic behavior and physiology or via intrinsic factors within the neural progenitor cells such as the redox state and clock genes/molecular clockwork. There is increasing evidence that the circadian system modulates the complex multistep process of adult neurogenesis, which is crucial for brain plasticity. ![]() ![]() The mammalian circadian system is a hierarchically organized system, which controls a 24-h periodicity in a wide variety of body and brain functions and physiological processes.
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